This paper describes the application of eight statistical and machine-learning methods to derive computer models for predicting mortality of hospital patients with pneumonia from their findings at initial presentation. The eight models were each constructed based on 9847 patient cases and they were each evaluated on 4352 additional cases. The primary evaluation metric was the error in predicted survival as a function of the fraction of patients predicted to survive. This metric is useful in assessing a model’s potential to assist (...) a clinician in deciding whether to treat a given patient in the hospital or at home. We examined the error rates of the models when predicting that a given fraction of patients will survive. We examined survival fractions between 0.1 and 0.6. Over this range, each model’s predictive error rate was within 1% of the error rate of every other model. When predicting that approximately 30°K of the patients will survive, all the models have an error rate of less than 1.5%. The models are distinguished more by the number of variables and parameters that they contain than by their error rates; these differences suggest which models may be the most amenable to future implementation as paper-based guidelines. (shrink)

One characteristic of the transition from the Middle Paleolithic to the Upper Paleolithic in Europe was the emergence of representational charcoal drawings and engravings by Aurignacian and Gravettian artists. European Neanderthals never engaged in representational drawing during the Middle and Early Upper Paleolithic, a property that might reflect less developed visuomotor coordination. This article postulates a causal relationship between an evolved ability of anatomically modern humans to throw spears accurately while hunting and their ability to draw representational images from working (...) memory. Unlike Neanderthals, archaic and anatomically modern humans in sub-Saharan Africa adopted longer-range hunting practices using hand-cast spears as a compensation for the emergence of increasingly wary game. For Neanderthals, paleoclimatic fluctuations likely precluded consistent hunting of cold-adapted game, a property making game more approachable for close-range hunting with thrusting spears. As evidence of less historical wariness of humans, many of the species hunted by Neanderthals were eventually domesticated. Due to strong sources of natural selection on archaic and anatomically modern humans for effective hunting, the parietal cortex that integrates visual imagery and motor coordination expanded progressively, yielding the globular shape of the human cranium that is not evident in Neanderthals. To characterize how the cognitive properties employed for throwing spears and drawing line work are similar, the Upper Paleolithic drawings of animals in Chauvet cave, France, are discussed in the speculative context of how these artists engaged simultaneously in overt attention to guide their hand movements and covert attention to their mental images during the drawing process. (shrink)

The whole factual world of human affairs depends for its reality and its continued existence … upon the presence of others who have seen and will remember. … Without remembrance and without the reification which remembrance needs for its own fulfillment … the living activities of action, speech, and thought would lose their reality at the end of each process and disappear as though they never had been.Research on the relationship between public memory and collective identity is varied and extensive, (...) but one fairly prominent scholarly perspective coalesces around Hannah Arendt's idea that the practices of remembrance are the lifeblood of the polis.1 The stakes here are high, for it seems that without remembrance .. (shrink)

Psychoanalysis is often equated with Sigmund Freud, but this comparison ignores the wide range of clinical practices, observational methods, general theories, and cross-pollinations with other disciplines that characterise contemporary psychoanalytic work. Central psychoanalytic concepts to do with unconscious motivation, primitive forms of thought, defence mechanisms, and transference form a mainstay of today's richly textured contemporary clinical psychological practice. -/- In this landmark collection on philosophy and psychoanalysis, leading researchers provide an evaluative overview of current thinking. Written at the interface between (...) these two disciplines, the Oxford Handbook of Philosophy and Psychoanalysis contains original contributions that will shape the future of debate. With 34 chapters divided into eight sections covering history, clinical theory, phenomenology, science, aesthetics, religion, ethics, and political and social theory, this Oxford Handbook displays the enduring depth, breadth, and promise of integrating philosophical and psychoanalytic thought. -/- Anyone interested in the philosophical implications of psychoanalysis, as well as philosophical challenges to and re-statements of psychoanalysis, will want to consult this book. It will be a vital resource for academic researchers, psychoanalysts and other mental health professionals, graduates, and trainees. (shrink)

John Etchemendy has argued that it is but "a fortuitous accident" that Tarski's work on truth has any signifance at all for semantics. I argue, in response, that Etchemendy and others, such as Scott Soames and Hilary Putnam, have been misled by Tarski's emphasis on definitions of truth rather than theories of truth and that, once we appreciate how Tarski understood the relation between these, we can answer Etchemendy's implicit and explicit criticisms of neo-Davidsonian semantics.

The paper formulates and proves a strengthening of ‘Frege’s Theorem’, which states that axioms for second-order arithmetic are derivable in second-order logic from Hume’s Principle, which itself says that the number of Fs is the same as the number ofGs just in case the Fs and Gs are equinumerous. The improvement consists in restricting this claim to finite concepts, so that nothing is claimed about the circumstances under which infinite concepts have the same number. ‘Finite Hume’s Principle’ also suffices for (...) the derivation of axioms for arithmetic and, indeed, is equivalent to a version of them, in the presence of Frege’s definitions of the primitive expressions of the language of arithmetic. The philosophical significance of this result is also discussed. (shrink)

Frege, famously, held that there is a close connection between our concept of cardinal number and the notion of one-one correspondence, a connection enshrined in Hume's Principle. Husserl, and later Parsons, objected that there is no such close connection, that our most primitive conception of cardinality arises from our grasp of the practice of counting. Some empirical work on children's development of a concept of number has sometimes been thought to point in the same direction. I argue, however, that Frege (...) was close to right, that our concept of cardinal number is closely connected with a notion like that of one-one correspondence, a more primitive notion we might call just as many. (shrink)

In this exciting new collection, a distinguished international group of philosophers contribute new essays on central issues in philosophy of language and logic, in honor of Michael Dummett, one of the most influential philosophers of the late twentieth century. The essays are focused on areas particularly associated with Professor Dummett. Five are contributions to the philosophy of language, addressing in particular the nature of truth and meaning and the relation between language and thought. Two contributors discuss time, in particular the (...) reality of the past. The last four essays focus on Frege and the philosophy of mathematics. The volume represents some of the best work in contemporary analytical philosophy. (shrink)

Gottlob Frege's Grundgesetze der Arithmetik, or Basic Laws of Arithmetic, was intended to be his magnum opus, the book in which he would finally establish his logicist philosophy of arithmetic. But because of the disaster of Russell's Paradox, which undermined Frege's proofs, the more mathematical parts of the book have rarely been read. Richard G.

In Mind and World, John McDowell argues against the view that perceptual representation is non-conceptual. The central worry is that this view cannot offer any reasonable account of how perception bears rationally upon belief. I argue that this worry, though sensible, can be met, if we are clear that perceptual representation is, though non-conceptual, still in some sense 'assertoric': Perception, like belief, represents things as being thus and so.

My purpose is to account for some oddities in what Kant did and did not say about "moral worth," and for another in what commentators tell us about his intent. The stone with which I hope to dispatch these several birds is-as one would expect a philosopher's stone to be-a distinction. I distinguish between two things Kant might have had in mind under the heading of moral worth. They come readily to mind when one both takes account of what he (...) actually said about it and notices a fact which he did not seem to notice: namely, that dutiful action- action which, whatever its motive, fulfills a duty-can be over- determined, and determined in particular by both respect for duty and some consortium of inclinations and prudenc. (shrink)

Written as a comment on Crispin Wright's "Vagueness: A Fifth Column Approach", this paper defends a form of supervaluationism against Wright's criticisms. Along the way, however, it takes up the question what is really wrong with Epistemicism, how the appeal of the Sorities ought properly to be understood, and why Contextualist accounts of vagueness won't do.

As is well-known, the formal system in which Frege works in his Grundgesetze der Arithmetik is formally inconsistent, Russell's Paradox being derivable in it. This system is, except for minor differences, full second-order logic, augmented by a single non-logical axiom, Frege's Axiom V. It has been known for some time now that the first-order fragment of the theory is consistent. The present paper establishes that both the simple and the ramified predicative second-order fragments are consistent, and that Robinson arithmetic, Q, (...) is relatively interpretable in the simple predicative fragment. The philosophical significance of the result is discussed. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:MetanoiaRichard G. T. Gipps, ClinPsyD, PhD (bio)A “honeysuckle on a broken fence”: Scrutton’s (2024) theologically potent image offers us a dignified vision of how a living faith and the experience of mental illness might intersect. Mental and physical illness, deprivation and bereavement sometimes provide a propitious structure on which faith’s bright strands may grow. Scrutton posits no simply causal relationship between faith and mental illness, and steers us helpfully (...) away from the narcissistic overvaluation of inner experience too often met with in (1) mysterium tremendum (meeting-God-blew-my-mind), and (3) mental openness (divine-light-pours-through-the-cracks), formulations. She helps us to avoid settling, too, for the clever-sounding but ultimately too-easy idea of (2) ‘mental illness’ and ‘religious experience’ as different descriptions under which identical experiences may sometimes be brought. For one thing, and to animadvert now in my own vein: can we really—as William James aspires to, say, when he takes it for granted that the “more personal branch [of] feelings, acts, and experiences of individual men in their solitude, so far as they apprehend themselves to stand in relation to... the divine” can be neatly hived off from the “institutional branch of religion... worship... theology... ceremony... ” and so on—even individuate the relevant experiential phenomena independently of their meaning-conferring contexts? For another, it seems to me that too often in the literature of (1) (2) and (3) do we meet with a fatal confusion that can be expressed in terms of a conflation of two meanings of “ego,” as when a) the dropping of the kinds of boundaries which it makes sense to talk of putting up (i.e., our ego’s defensive, prideful, shame-driven shirking of intimacy) is muddled together with b) the crumbling of such individuating ego boundaries as constitute us. Such a confusion gets readily promulgated by vague and tacitly polysemic talk not only of ‘ego’ but also of ‘non-duality,’ ’transpersonal,’ and ‘higher’ and ‘lower’ ‘levels’ of ‘self’ and ‘consciousness’ (e.g., see Kasprow & Scotton 1999). Sometimes driving this, one can’t help suspect, is the narcissistic gain of conflating the dismal dissolution of ego boundaries in illness (Conrad, 1958) with the epiphanic transcendence of a grasping and fearful ego. Spiritual pride and spiritual bypass (i.e. fleeing the relational tasks of adult development into a self-preoccupied ‘spiritualised’ inner journey) (Welwood, 2000) then abound, not only for the sufferer but also for the lowly therapist who now receives their shamanic guide/hierophant upgrade. By contrast with all of this, Scrutton’s (4) honeysuckle on a broken fence model stands out in its theological dignity and psychological sobriety.Even so I found myself, on reading Scrutton’s piece, wondering whether a more romantic conception of a growing faith’s possible relation [End Page 257] to psychological disturbance might yet be available and sometimes even find application. What particularly came to my mind was that notion of metanoia as offered us by the existential tradition in both theology and psychopathology.Mark’s gospel begins with John the Baptist heralding Christ’s arrival and preaching the “baptism of repentance [metanoia; μετανοίας] for the remission of sins” (Mark 1:4). Jesus’s first public words then proclaim the same message: “the kingdom of God is at hand: repent ye [μετανοεῖτε], and believe the gospel” (Mark 1:15). ‘Repentance’ is today often understood as a sorrowful acknowledgement of one’s wrongdoings, but it has long been acknowledged that, if that be the meaning we give the term, it is an inapt translation of ‘metanoia’ (Walden, 1896). For what the gospel instead calls for is rather a wholesale turning about, or conversion, from ‘ego-dominance to surrender’ (Barron, 2021), i.e. from (a) defensive and illusory attempts to handle our vulnerability and dependency through self-reliance and self-affirmation to (b) an aliveness to grace (i.e. seeing our lives and their bounties under the aspect of the freely given gift) and a trusting surrender to the dominion of that God of love in which we anyway inexorably ‘live and move and have our being’ (Acts 17:28). The ‘I’ in Paul’s “It is no longer I who... (shrink)

The book begins with an overview that introduces the Theorem and the issues surrounding it, and explores how the essays that follow contribute to our understanding of those issues.

Scaffolds are fundamental to many cellular signaling pathways. In this essay, a novel class of scaffolds are proposed, whose action bears striking resemblance to kinetic proofreading. Commonly, scaffold proteins are thought to work as tethers, bringing different components of a pathway together to improve the likelihood of their interaction. However, recent studies show that the cytoskeletal scaffold, anillin, supports contractile signaling by a novel, non‐tethering mechanism that controls the membrane dissociation kinetics of RhoA. More generally, such proof‐reading‐like scaffolds are distinguished (...) from tethers by a rare type of cooperativity, manifest as a super‐linear relationship between scaffold concentration and signaling efficiency. The evidence for this hypothesis is reviewed, its conceptual ramifications are considered, and research questions for the future are discussed. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Pathology of the Mind: Disorder Versus DisabilityRichard G. T. Gipps (bio)Keywordsorder, disorder, ability, disability, mental illnessAlfredo Gaete (2008) describes mental disorders as impairments in intentionality, phenomenal consciousness, and intelligence that cause harm to the affected person. I found persuasive Gaete’s claim that the concept of ‘mental disorder’ is best understood as nontheoretical and nontechnical. I also find compelling his argument that a previous contribution of my own—which relied in (...) part on specifying different senses of ‘disorder’ in psychological, physiological, and social cases—was misguided. Further, his suggestion that we ought at least to attempt analysis in terms of necessary and sufficient conditions before we seek out less definitive characterizations (in terms of family resemblances) also persuades me, although I find myself less sanguine than he about the general possibility of achieving such analyses.One of Gaete’s principal claims is that mental disorder is helpfully understood in terms of an absence of a capacity—that is, as a disability. There are two related objections—or two aspects of the same objection—that I would like to offer the author with respect to this claim. These may well not be conclusive, but will I hope at least function as foils against which the author can usefully sharpen his argument. One objection suggests that there is a viable distinction between the concepts of mental disorder and mental disability, as commonly used in clinical contexts, which the account offered seems unable to respect. The second suggests that the account may not be able to theorize what is argued to be the essential contribution of the concepts of order and disorder (as opposed to ability and disability) to the everyday concept of mental disorder. Accordingly, it questions the power of a disability approach such as Gaete’s to capture the essential nature of mental disorder.In his paper, Gaete classifies mental retardation and developmental, or (what in the United Kingdom are known as) learning, disabilities (autism, etc.) as cases of mental disorder. I found this surprising because it is not common linguistic practice in the psychological circles in which I operate. It would also seem to make a nonsense of commonly accepted ideas like: “Mental disorders are more likely to occur in patients with developmental disabilities (e.g., in autism, Asperger, or Down syndrome) than in the general population.” (For an example, see Campbell and Malone [1991]). On Gaete’s classification, it would appear that people with autism eo ipso have a mental disorder, and [End Page 341] hence the commonly accepted idea would need to be interpreted as merely a statement about comorbidities of different disorders of the same general (i.e., mental) type. But that is not, I believe, how the term is commonly used, and Gaete’s suggestion must therefore be treated as revisionary rather than descriptively analytical.One way of reconstructing a rationale underlying the distinction between mental disabilities and mental disorders is as follows. A developmental disability involves a failure of (certain aspects of) the mind to grow and reach an expected level or type of organization. A mental disorder by contrast involves a disturbance or disorganization (not simply an impoverishment) within the mind at whichever level of organization it has reached. As the mind develops, and reaches new levels or types of organization, the forms which mental disorders may take accordingly change.Autism and schizophrenia provide helpful illustrations of this distinction. Autism represents a failure of (among other things) the social mind to develop in childhood. The person with moderate to severe autism may attain at best a very shaky grasp on the realities of other minds and social conventions. That is, the degree of mental structure they obtain—their social competencies or capacities—will likely remain limited. It is this fundamental deficit that marks out the disability, and not the social anxieties or other such disturbances that can beset the autistic person.Schizophrenia, by contrast, tends to occur at late adolescence, when the individual has developed higher levels of—albeit often fragile—mental structure. Yet it is not the fragility of such mental structure, but rather the disruptions that can occur within such structures as have developed, that mark them out... (shrink)

A brief, non-technical introduction to technical and philosophical aspects of Frege's philosophy of arithmetic. The exposition focuses on Frege's Theorem, which states that the axioms of arithmetic are provable, in second-order logic, from a single non-logical axiom, "Hume's Principle", which itself is: The number of Fs is the same as the number of Gs if, and only if, the Fs and Gs are in one-one correspondence.

This book prints for the first time two remarkable interlocking sequences of letters between Paris and the Netherlands: 40 letters from Gilles Ménage in Paris to Johann-Georg Grævius in Utrecht, and 30 from the printer Henrik Wetstein, in Amsterdam, to Ménage. Their principal focus is the publication of a considerable number of Ménage's works outside France, above all his monumental edition of Diogenes Laertius's Lives of the Philosophers. The letters give an engaging picture of mutual help within the community of (...) scholars, Dutch, German, English, and French, including Huguenot exiles like Le Clerc and Bayle. Ménage's are full of information from Paris; while Wetstein's, forthright and humorous, concentrate on publishing details in a sometimes stormy relationship. The great Diogenes edition encountered an extraordinary range of problems: difficulties at every stage of publication, hazardous wartime communications, and, not least, a bizarrely eccentric collaborator in Marcus Meibomius. The two correspondences provide a fascinating case-study of the practical working of international scholarly publishing in time of war, and the European network of learned correspondence in the later seventeenth century. Each letter is printed in full, accompanied by a summary, detailed commentary, and extensive annotations. (shrink)

The purpose of this note is to present a strong form of the liar paradox. It is strong because the logical resources needed to generate the paradox are weak, in each of two senses. First, few expressive resources required: conjunction, negation, and identity. In particular, this form of the liar does not need to make any use of the conditional. Second, few inferential resources are required. These are: (i) conjunction introduction; (ii) substitution of identicals; and (iii) the inference: From ¬(p (...) ∧ p), infer ¬ p. It is, interestingly enough, also essential to the argument that the ‘strong’ form of the diagonal lemma be used: the one that delivers a term λ such that we can prove: λ = ¬ T(⌈λ⌉); rather than just a sentence Λ for which we can prove: Λ ≡ ¬T(⌈Λ⌉). The truth-theoretic principles used to generate the paradox are these: ¬(S ∧ T(⌈¬S⌉); and ¬(¬S ∧ ¬T(⌈¬S⌉). These are classically equivalent to the two directions of the T-scheme, but they are intuitively weaker. The lesson I would like to draw is: There can be no consistent solution to the Liar paradox that does not involve abandoning truth-theoretic principles that should be every bit as dear to our hearts as the T-scheme. So we shall have to learn to live with the Liar, one way or another. (shrink)

Today the concept of 'schizophrenia' is often presented in psychiatric texts as a construct, a construct bringing together a diverse and, allegedly, independently assailable range of signs and symptoms. According to such a diagnostic scheme two patients may both be allowed to count as suffering from schizophrenia despite sharing hardly a single symptom. The validity of the concept has accordingly been contested by psychologists for its apparent lack of unity. In the absence of clear independent evidence of a unitary physiological (...) disease process underlying such diverse phenomena, a natural enough suggestion has been to... (shrink)

The 1920-1960 period saw the creation of the conditions for a unification of disciplines in the area of evolutionary biology under a limited number of theoretical prescriptions: the evolutionary synthesis. Whereas the sociological dimension of this synthesis was fairly successful, it was surprisingly loose when it came to the interpretation of the evolutionary mechanisms per se, and completely lacking at the level of the foundational epistemological and metaphysical commitments. Key figures such as Huxley, Simpson, Dobzhansky, and Rensch only paid lip (...) service to the conceptual dimension of the evolutionary synthesis, as they eventually realized that a number of evolutionary phenomena could not be explained by its narrow theoretical corpus. Apparently, the evolutionary synthesis constituted a premature event in the development of evolutionary biology. Not only are the real achievements of the evolutionary synthesis in need of reevaluation, but this reassessment also has important implications for the historiography of Darwinism and the current debates about the darwinian movement. (shrink)

Hartry Field has suggested that we should adopt at least a methodological deflationism: "[W]e should assume full-fledged deflationism as a working hypothesis. That way, if full-fledged deflationism should turn out to be inadequate, we will at least have a clearer sense than we now have of just where it is that inflationist assumptions... are needed". I argue here that we do not need to be methodological deflationists. More precisely, I argue that we have no need for a disquotational truth-predicate; that (...) the word 'true', in ordinary language, is not a disquotational truth-predicate; and that it is not at all clear that it is even possible to introduce a disquotational truth-predicate into ordinary language. If so, then we have no clear sense how it is even possible to be a methodological deflationist. My goal here is not to convince a committed deflationist to abandon his or her position. My goal, rather, is to argue, contrary to what many seem to think, that reflection on the apparently trivial character of T-sentences should not incline us to deflationism. (shrink)

Salivary testosterone levels were measured in a population of New World indigenous adult hunter-gatherer males in order to compare circulating levels of free unbound bioactive steroid with those previously reported among Boston and nonwestern males. The study population consisted of adult Aché hunter-gatherer males (n=45) living in eastern Paraguay. Morning and evening salivary testosterone levels (TsalA.M.; TsalP.M.) among the Aché were considerably lower than western values (Boston) and even lower than other previously reported nonwestern populations (Efe, Lese, Nepalese). No association (...) was observed between height, weight, or age and salivary testosterone levels within the Aché group, although older men (ages>40) were poorly represented in the study sample. Nevertheless, a mild correlation was observed between Aché TsalA.M. levels and BMI (r=0.133,p=0.0725). Comparison of Aché values with those for other populations confirms the prevalence of significant interpopulational variation in testosterone levels among adult males. Interpopulational variation in male testosterone is not as great, however, as has been documented for ovarian steroids among females, nor is it likely that such variation reflects differences in male fecundity. Nevertheless, such interpopulational variation in salivary testosterone levels may have a functional significance in the regulation of protein anabolism in skeletal muscle, thereby affecting the overall energy budget of the organism. It is suggested that relative suppression of average testosterone may be adaptive under conditions of chronic energy shortage. (shrink)

Tversky and Koehler's support theory attempts to explain why probability judgments are affected by the manner in which formally similar events are described. Support theory suggests that as the explicitness of a description increases, an event will be judged to be more likely. In the present experiment, experienced decision-makers from large, international accounting firms were given case-specific information about an audit client and asked to provide a series of judgments regarding the perceived likelihood of events. Unpacking a hypothesis into four (...) formally equivalent hypotheses more than doubled its perceived likelihood. These results are largely consistent with support theory, extending its generalizability to applied contexts involving business professionals. Further, the paper finds that task-specific factors, a previously untested area, can also affect support theory interpretations. (shrink)

Some years ago, Machery, Mallon, Nichols, and Stich reported the results of experiments that reveal, they claim, cross-cultural differences in speaker’s ‘intuitions’ about Kripke’s famous Gödel–Schmidt case. Several authors have suggested, however, that the question they asked their subjects is ambiguous between speaker’s reference and semantic reference. Machery and colleagues have since made a number of replies. It is argued here that these are ineffective. The larger lesson, however, concerns the role that first-order philosophy should, and more importantly should not, (...) play in the design of such experiments and in the evaluation of their results. (shrink)